Relationship between L-type Ca2+current and unitary sarcoplasmic reticulum Ca2+release events in rat ventricular myocytes
نویسندگان
چکیده
منابع مشابه
Dynamic Changes in Sarcoplasmic Reticulum Structure in Ventricular Myocytes
The fidelity of excitation-contraction (EC) coupling in ventricular myocytes is remarkable, with each action potential evoking a [Ca²⁺](i) transient. The prevalent model is that the consistency in EC coupling in ventricular myocytes is due to the formation of fixed, tight junctions between the sarcoplasmic reticulum (SR) and the sarcolemma where Ca²⁺ release is activated. Here, we tested the hy...
متن کاملSarcoplasmic Reticulum Ca21 Uptake and Thapsigargin Sensitivity in Permeabilized Rabbit and Rat Ventricular Myocytes
Ca'+ uptake by the sarcoplasmic reticulum (SR) and free [Ca2"] were measured simultaneously with indo 1 and a Ca'+-selective minielectrode in suspensions of permeabilized rabbit or rat ventricular myocytes ('-'10 mg/mL protein). In the presence of 25 ,umol/L ruthenium red and 10 mmol/L oxalate, the K. for Ca2 uptake by the SR was '250 nmol/L in rabbit and rat ventricular myocytes. The maximal C...
متن کاملSarcoplasmic reticulum Ca release in intact ventricular myocytes.
Sarcoplasmic reticulum (SR) Ca release in intact ventricular myocytes is the major source of Ca which activates cardiac contraction (although Ca influx makes a non-negligible contribution in most species). The fundamental events of SR Ca release are known as Ca sparks. The twitch Ca transient is composed of approximately 10,000 Ca sparks occurring in a given cell, and they are synchronized by t...
متن کاملSarcoplasmic reticulum Ca2+ uptake and thapsigargin sensitivity in permeabilized rabbit and rat ventricular myocytes.
Ca2+ uptake by the sarcoplasmic reticulum (SR) and free [Ca2+] were measured simultaneously with indo 1 and a Ca(2+)-selective minielectrode in suspensions of permeabilized rabbit or rat ventricular myocytes (approximately 10 mg/mL protein). In the presence of 25 mumol/L ruthenium red and 10 mmol/L oxalate, the Km for Ca2+ uptake by the SR was approximately 250 nmol/L in rabbit and rat ventricu...
متن کاملon the relationship between iranian learners personality type and communication strategies in speaking.
چکیده شخصیت به مجموعه عوامل روانی، عقلی، احساسی، و فیزیکی تشکیل دهنده یک فرد اطلاق میشود، خصوصا فرد ازدیدگاه دیگران ( مرجع). تدابیر یاد گیری سعی در اگاهی از اقدامات زبان اموزان موفق زبان دوم یا یک زبان بیگانه را دارد که توسط خود زبان اموزان گزارش میشود،یا حین یادگیری زبان دوم یا زبان بیگانه از انها قابل مشاهده است( روبین و وندن 1987). همچنین تدابیر ارتباطی به زبان اموزان کمک می کند تا بر مشکلا...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1999
ISSN: 0022-3751
DOI: 10.1111/j.1469-7793.1999.117aa.x